Hill's - over 60 years experience developing foods that help promote a healthy urinary environment

13 March 2018

Managing patients with multiple disease conditions can be challenging. The S+OXSHIELD™ seal provides you with additional confidence when recommending the appropriate Hill’s™ Prescription Diet™ foods.  The foods containing the S+OXSHIELD seal meet specific nutrient standards shown to promote a urinary environment that helps reduce the risk for struvite and calcium oxalate crystals. The nutrition profile is based on standards developed through feeding tests in dogs and cats that use relative supersaturation (RSS), the calcium oxalate titration test (COT)1 and urine pH as endpoints.

The Hill’s calcium oxalate titration (COT) test measures the likelihood for calcium to precipitate in the urine. The COT test is based on the human Bonn Risk Index (BRI) which can correctly segregate 70% or more of those people likely to form a second stone from those that do not.2 Because whole urine is used in this test, it takes into consideration all of the inhibitors and promoters present in urine that may affect calcium oxalate crystal formation. Together with RSS, this test has allowed us to gain a more complete understanding of the saturation and stability of urine and the risk for calcium oxalate crystal formation.

While the S+OXSHIELDseal is a helpful tool for identifying urinary appropriate foods for pets with other specific nutritional needs, we still recommend feeding our urinary foods (Hill’s Prescription Diet™ c/d™ Multicare Canine and Feline, Metabolic + Urinary Feline, etc.) when the pet does not have any other underlying medical condition. These foods have additional features such as struvite dissolution and EPA and DHA from fish oil. Additionally, the nutrition of Hill’s™ Prescription Diet™ c/d™ Multicare Feline has been shown to reduce the rate of recurrent FIC signs by 89%.3

Visit Hill's at the AVA conference - stands 94, 95, 96, 97.


  1. Davidson SJ, MacLeay JM. The calcium oxalate risk index: A new method for determining the propensity for formation of calcium oxalate uroliths. J Vet Intern Med 2014; 28:1083.
  2. Laube et al A New Approach to Calculate the Risk of Calcium Oxalate Oxalate Crystallization From Unprepared Native Urine. Urol Res 2000; 28: 274-280. 
  3. Kruger JM, Lulich JP, MacLeay JM et al. Comparison of foods with differing nutritional profiles for long-term management of acute non-obstructive idiopathic cystitis in cats. J Am Vet Med Assoc 2015; 247:508-517.


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